Angie was on a flight when she met David Hasselhof, who offer her the female leading part in his show Baywatch Nights even though she had no acting experience. She always believed that modeling would be her ticket to acting, so she accepted .Today she considers that working on Baywatch Nights was 44 lessons of hitting her mark. Angie learned those lessons well ,after Baywatch Nights she she portrayed Pamela Gregory in her fist movie Lawn Dogs directed by John Duigan and from the producer of 4 weddings and a funeral.

At 22 years old, Harmon was hired for the role after her audition, preparing to make her network television debut. In 1995, the same year that Baywatch Nights debuted, Harmon made guest appearances on Baywatch and the television series Renegade. After her role as detective Ryan McBride on Baywatch Nights, Harmon starred in the television series C-16 in 1997, co-starring Eric Roberts. That same year, Harmon made her move to the big screen. Her first film role was in the independent film named Lawn Dogs, directed by John Duigan.

The film received a lot of exposure, as it was screened at the prestigious Toronto Film Festival and the Sundance Film Festival. While appearing on The Tonight Show on March 13, 2000, Harmon's boyfriend (football player) Jason Sehorn. Surprised Harmon by proposing to her on the show. Leno, who was in on the plan, had just asked her if she was dating anyone special, to which she responded that she doesn't discuss her personal life in public.

She accepted the marriage proposal on national television. Harmon and her New York Giants defensive back fiancé were introduced by Sehorn's mother.